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Menopause results from the loss of ovarian follicular function and a decline in circulating estrogen levels

GCGR activation stimulates hepatic glucose production between meals, increases lipolysis and fatty acid oxidation in the liver, elevates basal energy expenditure, and promotes thermogenesis

Connelly KA, Advani A, Zhang Y, Advani SL, Kabir G, Abadeh A, Desjardins JF, Mitchell M, Thai K, Gilbert RE

Efficacy and safety of monotherapy with the novel sodium/glucose cotransporter-2 inhibitor Tofogliflozin in Japanese patients with type 2 diabetes mellitus: a combined phase 2 and 3 randomized, placebo-controlled, double-blind, parallel-group comparative study

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