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The presence of HO-1 significantly reduces the levels of inflammatory markers associated with diabetic wounds such as TNF-, IL-1, IL-6, iNOS, COX2, MCP-11, and MIP-1, while simultaneously boosting the levels of IL-10 [126]

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Upon binding, IGF-1R undergoes autophosphorylation, recruiting insulin receptor substrate (IRS) proteins and Shc adaptor molecules

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