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G.JunotC.GodatE.et al (2011)

No published study has tested this split approach directly, but the pharmacological logic holds: maximize both local concentration and systemic delivery

However, under conditions of hypoxia-induced ROS, Nrf2 dissociates from Keap1, translocates into the nucleus, and binds to musculoaponeurotic fibrosarcoma protein (Maf)