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The pathogenesis involves a breakdown of self-tolerance, enhanced antigen presentation, T and B lymphocyte activation, autoantibody production, and cytokine-mediated thyroid tissue damage
Uric acid is a selective antioxidant ( Figure 3 ) that removes superoxide by preventing the degradation of superoxide dismutase and subsequently inhibits its reaction with NO to form peroxynitrite (van der Veen et al., 1997)
The formulations were designed to deliver therapeutically relevant doses for translational evaluation in a rat model of insulin-impaired diabetes
M., Achy, S
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