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The increased levels of norepinephrine, dopamine, and serotonin in the hypothalamus, specifically in the arcuate nucleus, lead to the activation of neurons that express pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART)
Methods Experimental approach Using a random number generator (www.random.org), in a double-blind, placebo-controlled design, 75 resistance-trained males between the ages of 18 and 35 were randomly assigned to ingest L-citrulline malate, L-citrulline + GSH, or placebo while also participating in 8 weeks of resistance training
A.CorcoranD
The thinking: if the incretin pathway has reached maximum effect, stimulating a completely different pathway might restart progress without the gastrointestinal burden of higher tirzepatide doses
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