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Most tirzepatide side effects especially GI events like nausea, diarrhea, and constipation peak in the first 1 to 2 weeks of starting and after each dose increase

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When to Involve Your Healthcare Provider Constipation lasting beyond 10-14 days, severe abdominal pain, or signs of impaction (hard stools, straining, incomplete evacuation) warrant immediate provider contact

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"That $150 billion pie is gone, even if youre very bullish on volumes," said Jefferies analyst Michael Leuchten