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Currently, have evolved from antidiabetic drugs into a platform-type therapy covering obesity, cardiovascular, and renal protection (7577)
In a statement to Insider, Novo Nordisk, the company that makes Wegovy and Ozempic, said that Gila monsters and the discovery of exendin-4 "did not have anything to do with our decision to develop long-acting GLP-1 receptor agonists" for obesity, because "that was based on GLP-1 biology in humans." But the company also said that "the GLP-1-like effect of exendin-4" in Gila monsters was "an important contribution to the field," as it led to the development of the very first injectable drug of its kind
Scandinavian Journal of Clinical and Laboratory Investigation, 65 (sup240), 99106
Dose increases typically occur every 4 weeks, following the clinical trial schedule
