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Yang C, Zhang X, Ge X, He C, Liu S, Yang S, et al

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REDEFINE 1 Combination Data The closest analog for layered amylin + incretin tolerability is REDEFINE 1, where cagrilintide 2.4 mg was paired with semaglutide 2.4 mg: The pattern: layering cagrilintide on a GLP-1 backbone produced modestly more GI events than the GLP-1 alone, but discontinuation rates were similar

Several pieces of scientific evidence support this

Correcting Metabolic Disorders and Reducing Bodily Burden: Most myocardial infarction patients suffer from metabolic abnormalities such as obesity and insulin resistance