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NDP-alpha-MSH) is a linear analog of alpha-MSH with Nle4 and D-Phe7 substitutions that confer increased MC1R binding affinity and metabolic stability compared to native alpha-MSH
Both studies continue to demonstrate no evidence of weight loss plateau
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In the second, lipidated, analogue, G002, the N-terminal was conjugated with trans-3-hexenoic acid, and in position 14, leucine was replaced by octyl glycine
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