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There are other, perhaps more common, genetic variants associated with the risk of developing ADincluding the late onset form of the disease (LOAD)such as ApoE4 [521, 522] or those identified more recently (e.g., mutations in CD36 [523], see [524] for review)
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GCN2 is a kinase which senses amino acid limitation, while PERK is activated in response to ER stress 15
