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In a trial of patients with T2DM and a BMI of 27 kg/m2 or greater being treated with semaglutide injection for weight loss, clinically significant hypoglycemia (plasma glucose less than 54 mg/dL) was reported in 6.2% of semaglutide-treated patients versus 2.5% of placebo-treated patients
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This requirement is in place because bacteriostatic water is used to dilute or reconstitute injectable medications, and improper use without medical supervision can pose significant health risks
PLoS ONE 7 , e36764 (2012)
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