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Semaglutide , taken weekly: Possibly the most well-known of them all, FDA-approved under the brand names Ozempic for type 2 diabetes and to reduce the risk of a major adverse cardiovascular event in adults with type 2 diabetes or an established cardiovascular disease and Wegovy for obesity

While those studies measured endogenous GLP-1 in blood samples rather than pharmaceutical preparations, the principle holds: peptides and temperature are not friends

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Even so, these medications are still only influencing part of a much more complex system, which is why responses can vary from one person to another