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Second, protein aggregates can trigger immune responses, potentially causing injection site reactions or, in rare cases, the development of anti-drug antibodies that neutralize future doses

Often people who take these medications lose not only fat but also muscle due to insufficient protein, says Reyna Franco, a registered dietitian nutritionist and certified personal trainer with a private practice in New York

Patients in clinical trials, such as Sustain 7 and Step 1, secured impressive results, ranging from over 14 pounds lost on average in 40 weeks with a stand-alone GLP-1 program to up to 44 pounds in 68 weeks with GLP-1 combined with diet and exercise