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This is because when people lose weight, the bodys natural inclination is to return to its previous weight a phenomenon called metabolic adaptation

Science 367 , 13621366 (2020)

Study of MDA-LDL by pioglitazone and pitavastatin in patients with type 2 diabetes

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The aspects described above, such as a demonstrated reduction of cardiovascular risk, limitations on their use in renal failure, nephroprotection or complexity are all addressed in the table of available antidiabetic agents