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This FOXO4-mediated nuclear retention of p53 is a key mechanism by which senescent cells maintain apoptosis resistance despite their dysfunctional state

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Hydrophobic residues in p53 TAD2 are critical for interaction with FOXO4 FHD Based on the significance of both the TAD2 region and the C-terminus of p53 in interacting with the FOXO4 FHD, we attempted to develop an inhibitor targeting the FOXO4-p53 interaction

Pinealon a peptide bioregulator studied in neuro research