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At the same dose, a 74 kg participant had about 1.4 times the exposure of a 110 kg reference, while a 143 kg participant had about 0.8 times. Weight alone does not set the dose, but it helps explain why the trial mean transfers poorly to bodies outside the studied range

Each batch is analytically verified to ensure purity and consistency, supporting accurate and reliable experimental applications

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While initially protective, prolonged UPR induces apoptosis

Cells were fixed with 4% PFA for 30 minutes, permeabilized with 0.1% Triton X-100, and blocked with 5% normal goat or donkey serum