At the currently approved maximum dose of 14mg, the PIONEER clinical trials showed weight loss of approximately 4-5kg (about 4-5% of body weight) over 26 weeks in patients with type 2 diabetes
While some of the trials reported a decrease in appetite as a side effect, like the ADJUNCT trials (58, 60), it should be noted that this is one of the main mechanisms of action of these drugs to achieve weight loss
Dosing doesn't translate into humans
SIDE EFFECTS Short term side effects after administration include: Facial flushing Reduced appetite, nausea and vomiting In males, spontaneous erections 1-5 hours after administration (priapism), associated with yawning and stretching complex Long term, there is concern that melanotan II may increase the risk of: Melanoma a potentially serious form of skin cancer Deepening of the color of moles, new moles and atypical melanocytic naevi Melanonychia brown to black discoloration of one or more nails Suggested usage: daily for 1 - 2 weeks then one to two times weekly for maintenance
In addition to an adequate diet and physical training, L-Carnitine + Chromium (60 caps) from Biotech USA contributes to greater calorie utilization and to gaining energy from fat mass