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Gutorgan communication is further modulated by neuroendocrinemetabolic reprogramming, including changes in autonomic and vagal signaling, gut hormone secretion, nutrient sensing, and host metabolic pathways [366]

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Strikingly, reduced production of IL-21 by CD4 + T cells, and decreased frequency of IFN--expressing CD4 + T cells and CD8 + T cells were observed in the presence of L-Cn ( Figures 3C, D )