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We recommend gradual titration starting low and increasing slowly to improve tolerability

Speed of effect: IV raises plasma levels within minutes

Pioglitazone and risk for bone fracture: safety data from a randomized clinical trial

Results The proportions of patients who discontinued study drug in Studies 2, 3, and 4 was 16.0% for the WEGOVY-treated group and 19.1% for the placebo-treated group, and 6.8% of patients treated with WEGOVY and 3.2% of patients treated with placebo discontinued treatment due to an adverse reaction [see Adverse Reactions (6.1)]

These side effects may go away during treatment as your body adjusts to the medicine