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AOD-9604 Research Protocols & Administration Dosing in Published Research Research investigations have employed diverse AOD-9604 doses across species and administration routes: Rodent studies: 250-500 mcg/kg orally or intraperitoneally was most common for obesity research Rabbit models: 0.25 mg per joint for osteoarthritis studies (intra-articular injection) Pig pharmacokinetic studies: 1.5 mg/kg IV and 2 mg/kg oral for metabolism characterization Human clinical trials: Oral doses of 0.25-10 mg daily

Based on investigational protocol reports and the clinical trial data, most subjects begin to see measurable changes in body composition at 4 to 6 weeks on a consistent daily protocol at 300 mcg

The risk of photolysis Even though B12 is very stable when dry, it is also extremely light-sensitive in liquid form

Holding the needle parallel to the body, carefully insert the needle into the skin and inject the B12

Some studies suggest AOD-9604 may support collagen synthesis in chondrocytes and reduce joint inflammation, which could be a secondary benefit for anyone carrying excess weight that stresses their joints