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This skin darkening is generally reversible with the help of B12 shots
Circulating levels decline with age, from roughly 200 ng/mL at age 20 to about 80 ng/mL by 60. Small split-face human dermatology studies, usually with fewer than 50 participants per arm, report changes in wrinkle depth and skin density
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Melanotan II and kisspeptin have sex-specific effects on reproductive hormones and should be discussed with an endocrinologist
The break is not required for safety or receptor resensitization, but it allows for reassessment and prevents indefinite use of a compound with limited long-term human data
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