Potential Side Effects While there are no large randomized controlled studies, some common side effects reported include injection-site reactions (pain, erythema, swelling), headache, nausea, diarrhea, and rare hypersensitivity reactions
Ranieri, S
Growth hormone secretion from the anterior pituitary gland is controlled by two primary opposing signals: Growth hormone-releasing hormone (GHRH): Produced by the hypothalamus, GHRH stimulates GH synthesis and release from pituitary somatotroph cells Somatostatin: Also produced by the hypothalamus, somatostatin inhibits GH release, creating a pulsatile pattern of secretion A third regulatory pathway involves ghrelin and growth hormone secretagogues (GHS) , which act through a separate receptor system (GHS-R1a) to amplify GH release independently of GHRH (1)
In research models the GHRH analogue increases the release that comes free per stimulus, while the ghrelin receptor agonist adds a second, independent stimulus
A food supplement should not be used as a substitute for a varied diet