The absorption of this vitamin is a complex process that involves the stomach, pancreas, small intestine, and liver, so if any one of those organs isnt functioning well, less B12 gets absorbed
Some people also notice an improvement in their overall sense of well-being and a reduction in symptoms associated with deficiency, such as tingling or numbness in the extremities
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FEBS Lett 585:33283336
During the subacute and chronic phases, astrocytes, microglia, macrophages, endothelial cells, pericytes, oligodendrocytes, and surviving neurons continue to remodel substrate utilization