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Succinate is oxidized by complex II to make CoQH 2 , which donates electrons for the RET process
Li L , Muftuoglu M, Jiangxing LV, Ayoub E, Bidikian A, Menon P, Basyal M, Bedoy A, Tyagi A, Eckstrom A, Battula VL, Issa G, Varadarajan N, Carter B, Andreeff M
While both compounds demonstrate remarkable individual efficacy and work through complementary mechanisms that theoretically could synergize, the complete absence of clinical trial data makes any combination approach purely experimental
The temporal aspects of healing also favor combination approaches
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