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In native GLP-1, DPP-4 cleavage occurs precisely at position 8 - the site where Aib now resides in semaglutide
Prospective data from the Longitudinal Assessment of Bariatric Surgery (LABS) Study [113] and the Dutch Audit for Treatment of Obesity (DATO) registry [114] show wide interindividual variation in post-surgical trajectories despite comparable procedures, highlighting the need for psychological risk stratification
These findings strengthen the need to continue studying semaglutide and other metabolic therapies in advanced liver disease, says Loomba
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