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The upregulated Pt transporters [e.g., organic cation transporters (OCTs), multidrug and toxin extrusion proteins (MATEs), and copper transporters 1/2 (Ctr1/2)] in DGR increase the accumulation of Pt drugs in peripheral nerves as the first step to induce PIPN (Sprowl et al., 2013
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Like Ozempic and the others, its a GLP-1 medication, one that has been shown to lower blood sugar levels and induce weight loss
Los agonistas GLP-1 pueden producir elevaciones modestas de la frecuencia cardaca, aunque la relevancia clnica es incierta.Paradjicamente, estos frmacos han demostrado reducir eventos cardiovasculares mayores en poblaciones de alto riesgo
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