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Selected secondary supportive efficacy end points not included in the statistical testing hierarchy were the changes in body weight (expressed as percentages and kilograms), BMI, BMI as a percentage of the 95th percentile (a measure of the exact percentage above the 95th percentile for a given age and sex) according to sex- and age-specific growth charts, 22 BMI standard-deviation score, 23 waist circumference, blood pressure, glycated hemoglobin level, lipid levels, and alanine aminotransferase (ALT) level
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To fill this gap, the FDA allowed compounding pharmacies to step in and offer compounded semaglutide, a custom version of the medication
The present analyses were restricted to participants randomized to the semaglutide arm of SUSTAIN-6 who survived to week 56 and had complete covariate data and excluded participants in the placebo-treated arm
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