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346 In parallel, modulation of microbial metabolites offers therapeutic leverage: promoting beneficial compounds such as 3-IAA, which enhances ROS and chemosensitivity, or suppressing lactate-secreting strains such as Lactobacillus iners may reverse resistance-associated metabolic reprogramming

OLs are also influenced by neighbouring cells that shape the microenvironment by secreting growth factors and components of the extracellular matrix (ECM)

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Research on winter sports athletes reveals a high prevalence of respiratory symptoms and airway hyperresponsiveness, likely related to chronic cold air exposure during high-intensity breathing

Specifically, it up-regulates CPT1 mRNA expression, thereby promoting mitochondrial fatty acid transport and enhancing -oxidation activity (25, 26)