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Superoxide dismutase (SOD) catalyzes the dismutation reaction of superoxide anion radicals: 2- + 2- = 2 + 22 During the reaction, hydrogen peroxide is formed, which is able to inactivate SOD, so SOD always works in tandem with catalase, which quickly and efficiently breaks down hydrogen peroxide into neutral compounds: 2H2O2 = 2H2O + O2 The property of SOD to reduce the formation of peroxynitrite is due to its ability to reduce the concentration of the superoxide radical in the cell, which also limits its availability for the Fenton reaction

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First, CPT1 siRNA was used in this experiment, and we found that treatment with 2.5 mM l-carnitine significantly decreased the cellular ROS content (Fig

The main NRF2-activating drug candidates that have been explored, and many of which have reached different stages of clinical trials, are presented in Table 1

This is particularly beneficial for individuals experiencing chronic fatigue or those recovering from illness