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Calcium, diacylglycerol, cAMP and various phosphate derivatives of myoinositol (phosphatidylinositol and others) are essential secondary messengers involved in the regulation of intracellular signaling cascades, in response to the activation of the TSHR, and are necessary for the production H 2 O 2 and TG synthesis (56)

Regarding fat taste, mediated by CD36, healthy individuals exhibit increased oxygen consumption in the secondary gustatory cortex (orbitofrontal and medial prefrontal cortex) following oral fat intake

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Some patients experience mild discomfort at the injection site, temporary flushing or a metallic taste during the infusion