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A rather simple but very effective method of removing dominant epitopes to enhance responses to conserved subdominant epitopes involved the removal of the S1 portion of spike containing the RBD and then the administration of a vaccine with only S2 as a DNA vaccine or protein [73] (Table 2)
The FDA stated it lacks sufficient information to know whether the drug would cause harm when administered to humans
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Information provided in this article reflects publicly available guidance as of the publication date and may not reflect the most current regulatory requirements
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