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The efficacy of this therapeutic combination was first validated in our breast cancer models, demonstrating that PHGDH wild type breast cancer cells do not respond to the therapeutic combination, whereas PHGDH-amplified breast cancer cells exhibited a synergistic sensitivity to suboptimal dosages of sertraline plus chloroquine (Figure S8A)
Results: A total of 26 laboratories from 19 countries responded to the survey 8 (42%) were from high income countries and 11(58%) were from low-middle income countries
The presence of NAFLD increases the incidence of type 2 diabetes and accelerates the development of complications in type 2 diabetes [5]
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Its job is specific: it inhibits an enzyme called NNMT nicotinamide N-methyltransferase that becomes overactive in fat tissue, especially as we age
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