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Zhang, J., Pavlova, N

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For most healthy individuals, long-term use of L-Carnitine is considered safe when taken at recommended doses

This theory also proposes that malfunction of an as yet undiscovered lactate shuttle within the NMJ may be a pathological feature of ALS, suggesting that supporting mitochondrial function may optimize lactate metabolism and combat the toxicity caused by accumulation of excess lactate

Excessive glucose level results in secretion of pro-inflammatory cytokines and swelling of pericytes [33], and subsequent destruction of retinal capillaries causes ischemia and induces neovascularization [34]