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A significant benefit in reducing death from cardiovascular causes was only shown in the LEADER trial with liraglutide (HR 0.78
Three studies highlight the disparities in findings: Study one A 1992 study published in the Journal of Clinical Endocrinology & Metabolism found that 1mg of sermorelin injected twice a day could elevate IGF-1 levels in elderly subjects (aged 60-78) to approach those of younger men (aged 22-33)
2017b;35:10708
Metformin (The Old Reliable) Metformin is a safe, cheap, and effective drug for insulin sensitivity
Dose reductions of insulin or sulfonylureas may be needed to prevent hypoglycaemia
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