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The loophole that allowed them to do so was Section 503 of the Food, Drugs & Cosmetics Act

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It is these poorly-understood processes involved in the transport of UA that are particularly important in determining the disposition and action of UA within the brain, but are unaccounted for in the assumptions of the MR studies

Real-world evidence from observational studies consistently shows that GLP-1 RA use is associated with reduced risk of hepatic decompensation even in patients with established cirrhosis, supporting cautious use in this population