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This copper-binding motif is critical: the apo-peptide (GHK without copper) shows substantially reduced biological activity in most in vitro assays, indicating that the metal center is required for receptor interaction and downstream signaling

Cloning and characterization of the gene encoding the IDH1 subunit of NAD(+)-dependent [PMID: 1644826] Laboratory literature summary: Cloning and characterization of the gene encoding the IDH1 subunit of NAD(+)-dependent isocitrate dehydrogenase from Saccharomyces

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It comprises 15 amino acids and has been described in the scientific literature as exhibiting notable stability under physiological conditions, particularly when compared with many endogenous peptide fragments, which has contributed to its use in experimental and preclinical research models