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doi: 10.1016/j.pharep.2014.04.005 38 SunM.WuW.LiuZ.CongY

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The absorption profile differs slightly, with potentially faster uptake but similar overall bioavailability

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Specifically, system xc is inhibited by high extracellular Glu concentration, and decreasing intracellular GSH leads to peroxidase 4 (GPX4) inhibition and lipoxygenase (LOX) activation

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In the hinge-latch hypothesis, the conformation of the Nrf2Keap1 complex is altered upon oxidative stress, implying that induction of target genes is only facilitated by newly synthesized Nrf2

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