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This adds to the difficulty in reconciling MS under a single pathophysiological umbrella, but also has implications for therapeutic design: this cytodegenerative component is not expected to respond to current anti-inflammatory disease-modifying drugs targeting acute/adaptive peripheral autoimmunity
Adults with clear health goals who pass a medical review and are not pregnant/breastfeeding
These are typically dose-dependent and diminish with time and proper titration
Iozzo, Birk, Soslowsky Decorin Expression Is Required for Age-Related Changes in Tendon Structure and Mechanical Properties Matrix Biol (2012)
