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Ito T, Ando H, Suzuki T, et al
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Retatrutides triple-receptor approach (GLP-1 + GIP + glucagon) delivered 28.7% weight loss in Phase 3 and addresses energy expenditure in ways that neither Semaglutide, Cagrilintide, or even Tirzepatide can touch
The hypothesis is that glucagon-receptor agonism adds a thermogenic / increased-energy-expenditure component on top of the GLP-1R/GIPR appetite-and-insulin effects
doi: 10.3389/fnagi.2017.00118 8 SjholmBennetLNilssonPM
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