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Houghton PJ, Morton CL, Tucker C, Payne D, Favours E, Cole C et al

Under the same experimental format as Figure 1e left column, except using a molar ratio of GSSSG and LASSS to HGF (1:8000), LASSS-treated HGF (Figure 1e right column, bar 9 ) displayed about 2-fold higher c-met binding than the control HGF level ( bar 8 , in which HGF just received the solvent) equivalent to the positive controls ( bars 2 and 2 in the left column)

The reasons: Receptor sensitivity: While GHK-Cu doesn't appear to cause receptor downregulation the way some peptides do, cycling is a general precaution to maintain responsiveness and avoid adaptations that might blunt benefits

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