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Neurological: melanocortin receptor activity and central signaling
After 48 weeks of treatment with olepotide, the average weight loss from baseline was as high as 19.3%, and the proportion of subjects who achieved a 25% weight loss was as high as 97.2%
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Benton CB, Khan M, Nogueras Gonzlez GM, Nazha A, Piao J, Ning J, Aung F, Jabbour E, Kadia TM, Borthakur G, Ravandi F, Pierce S, Komrokji RS, Steensma D, DeZern A, l Roboz G, Sekeres M, Andreeff M , Kantarjian H, Garcia-Manero G
Consistent with our findings, post-mortem measurements in a cohort of twenty individuals (10 ASD and 10 TDC, aged 5-38 years old) also did not show significant differences in GSH levels in the frontal, parietal, or occipital cortices(Chauhan et al., 2012), a useful validation of challenging in vivo MRS measures
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