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As an essential intracellular antioxidant, reduced glutathione (-L-glutamyl-L cysteinylglycine, GSH) synthesis requires the cystine/glutamate antiporter system (encoded by SLC7A11 ) to import cystine from the environment and reduce it to cysteine
About the authorView full bio Michael Stewart, MRPharmS Medicine Leaflet Review Manager Contractor, Pharmacist BPharm (Hons), MRPharmS Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years experience advising on medicines and medical conditions
Methods: A transverse aortic constriction (TAC) model of myocardial hypertrophy was established in vivo using C57BL/6 mice, while neonatal murine cardiomyocytes were stimulated with phenylephrine (PE) as an in vitro validation model system
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