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All melanocortin receptors are class A G-protein-coupled receptors signalling principally through Gs and adenylyl cyclase to raise intracellular cAMP, and MC4R is the subtype whose ligand-bound active-state architecture is best resolved, including a 2021 cryo-EM series that captured bremelanotide bound to full-length MC4R in complex with heterotrimeric Gs

Reference: Alpert A J, Gilbert H F

Better yet, a 0.5 mL syringe with 0.01 mL gradations (if available) provides the finest control

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