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This is due to the natriuresis that can occur as a side effect
What does not carry over is anything involving availability: free fraction in a serum-containing medium, duration of exposure, sensitivity to the binding proteins that cultured cells secrete into their own conditioned medium, and clearance behavior in vivo
The zona pellucida (ZP) is a glycoprotein matrix that surrounds mammalian oocytes and plays a fundamental role in regulating the fertilization process
Other mechanisms such as VPA-induced lipid peroxidation and glutathione depletion could also contribute to hepatotoxicity [59]
Cell Metab 2014;20:61425.ArticlePubMedPMC 45
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