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Biological actions of GLP-1, source: reference [1] Evolution of GLP1 GLP-1RAs Currently, there are nine GLP-1RAs approved for marketing worldwide (Table 1), mainly for the treatment of diabetes and obesity, of which tirzepatide is a novel dual GLP-1RA/GIPR agonist

Though this trial did not report reductions in heavy alcohol drinking days (main outcome), it showed a significant attenuation of brain activation to alcohol cues

These convergently expanded gene families are involved in detoxification, oxidative stress, metabolism and reception of stimuli

Target: Pituitary stimulation and systemic lipolysis

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