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There is substantial evidence that the InsR/IGF-1R axis can activate NF-B signaling in both immune and non-immune cells [72,73,74] (Fig

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Western blot analysis demonstrated that exposure to rotenone for 60 days resulted in a strong inhibition of Nrf2 expression, which was profoundly restored by co-administration of sulforaphane (50 mg/kg), in the cerebral cortex and striatum, respectively (Fig

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