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This ingredient is considered hypoallergenic and non-toxic
However, unlike NSAIDs, acetaminophen interferes with the peroxidase activity of COX isoenzymes, predominantly COX-2, with little clinical effect and depends to a great extent on the state of environmental oxidation (Table 1
10.1016/j.jphotochem.2016.10.021 13 BakirD.SilburnB.RussellJ.Archer-RandS.BarryJ.MaesT.et al (2022)
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