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doi: 10.1055/s-2007-972854

Important limitations include: Most evidence derives from preclinical or observational studies No randomized controlled trials specifically evaluate tirzepatide for autoimmune disease Mechanisms remain incompletely understood Clinical translation of anti-inflammatory effects is uncertain There is currently no established clinical evidence that tirzepatide effectively treats autoimmune diseases

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According to the International Diabetes Federation (IDF) in 2021, approximately 537 million adults aged 2079 worldwide have diabetes, which is expected to rise to 783 million by 2045 (Ogurtsova et al., 2022)