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292 In HCC, intracellular lactate triggers histone H3K18 lactylation, promoting HECTD2 transcription

In the context of lipid metabolism, hepatocytes in the PV area are primarily responsible for the oxidative metabolism of fatty acids, while hepatocytes in the CV area are predominantly engaged in lipid synthesis (Katz et al., 1983)

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Because the body continuously uses glutathione to neutralize free radicals and support detoxification, these elevated levels gradually decline as the antioxidant is consumed through normal biological processes