Cons: available primarily through 1st Phorm website, premium pricing, fucoxanthin research is still emerging (mostly animal studies with promising but limited human data)
Starting at the lowest dose (0.25 mg) and advancing gradually every 4 weeks gives your brain time to upregulate GLP-1 receptors without overwhelming sudden changes
In patients in whom the major therapeutic goal is the compelling need to minimize the therapeutic risk pf hypoglycaemia, DPP-4 inhibitors are recommended as second line therapy after metformin failure at the same level as second line treatment options with GLP-1 receptor agonists, SGLT-2 inhibitors, or TZDs
GLP-1 arm drives satiety + glucose-dependent insulin secretion
Perez cautions that "most people tolerate probiotics fine, but they still aren't risk-free." He notes that people with irritable bowel syndrome (IBS) or small intestinal bacterial overgrowth (SIBO), or who are immunocompromised, should be cautious with any probiotic and only take one under the guidance of a health care professional